| 초록 |
Gelatin-catechol (Gel-C) has been applied in fabricating thermal irreversible hydrogels. Nonetheless, emphasis was usually only placed on the contribution of catechol moieties while ignoring the gelatin backbone, whose unique temperature responsiveness is of vital importance to successive applications. In this study, we found that Gel-C still keeps the temperature responsiveness of gelatin, and a thermal reversible Gel-C hydrogel was formed by lowering the temperature. At the same time, the thermal irreversible Gel-C hydrogel could be made as well simply by lowering the temperature and increasing the pH without the need of adding any other external reagents or stimulus. By simulating the forming process of irreversible Gel-C in vivo, an in situ gelling system could be fabricated by lowering the local temperature of hydrogel with cold shock, thus, when combining with the adhesiveness of catechol groups, can realize target and localized molecular delivery with prolonged retention time. |
