| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.40 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Synthesis of Biodegradable Polymers for Nonviral Gene Delivery |
| 초록 |
There is an increasing demand for biodegradable polymers due to the large number of biomedical applications. Degradable nonviral gene carriers are required due to possible long-term delivery of a therapeutic gene that would necessitate the removal of the delivery system to circumvent cellular toxicities or organ damage that would occur over an extended time period. Poly(ethylene glycol) (PEG) has been conjugated to low molecular weight cationic poly(L-lysine) (PLL) to produce multi-block copolymers with biodegradable ester linkages. N, N-dimethylhistidine (His) was conjugated to the primary amines of PLL to improve the endosome-disrupting capabilities of the polymer. Novel monomers were synthesized to produce cationic poly(carbonate)s that have protonable primary amine group to condense DNA, secondary or tertiary amine group to provide endosomal buffering effect and biodegradable carbonate backbone linkage. Controls in polymer molecular weight were obtained by ring-opening anionic polymerization. |
| 저자 |
안철희1, 최이락1, 이민형2
|
| 소속 |
1서울대, 2인하대 |
| 키워드 |
biodegradable; gene delivery; PLL; PEG; polycarbonate
|
| E-Mail |
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