| 학회 |
한국재료학회 |
| 학술대회 |
2010년 봄 (05/13 ~ 05/14, 삼척 팰리스 호텔) |
| 권호 |
16권 1호 |
| 발표분야 |
D. Health and Biological Materials(생체 및 의용재료) |
| 제목 |
Preparation and Characterization of Chitosan Hydrogel on PCL/PLGA mat for Potential Skin Bioengineering |
| 초록 |
Chitosan is a widely used substance in biomedical studies for its biodegradability and anti-microbial properties. In this study, chitosan hydrogels were prepared with varying concentrations of 1% glutaraldehyde solution as crosslinking agent. Poly(lactic-co-glycolic acid), a highly biodegradable and biocompatible material, was combined with polycaprolactone to increase the mechanical strength of the polymer. Chitosan hydrogels were fabricated and combined with PCL/PLGA (80:20) electro-spun mat to create a bilayered structure for potential artificial skin application. The combined materials were fabricated in laboratory conditions and were characterized by its swelling studies, tensile strength, MTT assay and SEM visualization. Experimental results showed that the PCL/PLGA mat provided increased biocompatibility and mechanical strength to the bilayered structure. The chitosan-hydrogel layer can significantly provide solution to fluid loss issues for dermal replacement. |
| 저자 |
Rose Ann Franco1, Nguyen Thi Hiep2, Byong-Taek Lee3
|
| 소속 |
1Department of Biomedical Engineering and Materials, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
Chitosan hydrogel; PLGA; PCL
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| E-Mail |
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