| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Targeted cellular delivery of injectable enzyme nanoparticles for treating drug-induced hepatotoxicity and liver injury |
| 초록 | Direct delivery of proteins into cells has been considered an effective approach for treating the protein-related diseases. To achieve an efficient cellular delivery of the protein, a multifunctional carrier system having desirable stability, cell-targeting property and endosomal escape functions may be required. d-HA/SOD was synthesized by reacting catechol moieties of d-HA with surface amines of SOD. CaP/d-HA/SOD was successfully prepared and stabilized by preventing excessive growth of CaP and inter-particular aggregation. Cellular uptake of CaP/d-HA/SOD was significantly increased by CD44-mediated endocytosis and dissociation of calcium and phosphate ions. The nanoparticle achieved the efficient hepatic cellular delivery of SOD via a systemic administration and resulted in efficient removal of reactive oxygen species (ROS) in the liver and remarkable improvement of APAP-induced hepatotoxicity and liver injury. |
| 저자 | 정재백, 이민상, 김다훤, 정지훈 |
| 소속 | 성균관대 |
| 키워드 | Protein delivery; Systemic delivery; Targeted delivery; Calcium phosphate ions |
