| 초록 |
Cocrystals of salicylic acid (derived from reaction between aspirin and conformers) with 4,4dipyridyl, nicotinamide, isonicotinamide, N,N′-diacetylpiperazine and piperazine have been examined with intent to improve physicochemical properties of antipyretic agent. All of the resulting cocrystlas, salicylic acid/4,4dipyridyl (2:1), salicylic acid/nicotinamide (1:1), salicylic acid/isonicotinamide (1:1), salicylic acid/piperazine (1:0.5) and salicylic acid/ N,N′-diacetylpiperazine (2:1) (derived from reaction between aspirin and piperazine) are obtained solution cooling/evaporation experiments. The structural analysis has shown that the well-known COOH---N heterosynthon was considered the key element in the cocrystals design strategy. The crystal structures of the all cocrystals were determined by single-crystal X-ray. |
