| 학회 | 한국재료학회 |
| 학술대회 | 2010년 가을 (11/11 ~ 11/12, 무주리조트) |
| 권호 | 16권 2호 |
| 발표분야 | A. Information and Sensor Materials(정보소재 및 센서) |
| 제목 | Highly Sensitive Plastic Based FET Biosensors |
| 초록 | Point of care testing(POCT) are being studied with great interest for disease diagnosis such as complete blood count, routine chemistry test, glucose concentration, cancer, DNA and viruses. Essential elements of biosensor that suitable for POCT are portable, simple, highly sensitivity, rapid and real time detection. Considerable researches for biosensor such as surface plasmon resonance(SPR), enzyme-linked immunosorbent assay(ELISA), micro-cantilevers, surface-enhanced spectroscopies, and optical devices have been performed significantly over last decades. Each of these methods, however, has yet demonstrated the combination of POCT features such as label free, highly sensitivity, simple, quick and real-time detection of biomolecules. Field effect transistor (FET) type biosensors1) offer opportunities to develop suitable for POCT by overcoming the deficiencies of above mentioned approaches. Regardless of these merits, FET type biosensors have limit of applications because they are fabricated on non biocompatible, brittle and expensive substrates such as Silicon or SOI wafers. Rogers and coworkers reported microstructured semiconductors (μs-Sc) technologies for the high performance flexible electronics by transferring ultrathin single crystal Si ribbons onto plastic substrates by using standard microfabrication and soft lithographic printing technique.2) Herein, we report an approach that highly sensitive FET biosensors utilizing single crystal μs-Si transistors and silica binding protein(SBP)3) immobilization were fabricated on plastic substrates combined with microfluidic technologies for detecting bioreceptor molecule of avian influenza(AI) antigen. From the results, we demonstrate plastic based FET biosensors suitable for POCT and substrate-free bio-compatible applications. Reference 1) E. Stren et. al., Label-free immunodetectionwith CMOS-compatible semiconducting nanowires, nature, 2007, 445, 519 2) K.J Lee et. al., Large area, selective transfer of microstructured silicon : A printing-based approach to high performance thin film transistors supported on flexible substrates, Adv. Mater., 2005, 17, 2332 3) B.S Gu, T.J Park et. al., Nanogap field-effect transistor biosensors for electrical detection of avian influenza, Small, 2009, 5, 2407 |
| 저자 | 이상용1, 유현균1, 박태정2, 이건재3 |
| 소속 | 1한국과학기술원, 2한국과학기술원 화학생명공학과, 3한국과학기술원 신소재 공학과 |
| 키워드 | biosensor; FET; flexible |
