| 초록 |
Cell fate depends on various factors, including chemical factors and physical stimuli. Especially, appropriate external physical stimulation is critical for cells to be engineered in tissue engineering approaches. In this study, 3D printable self-healing ferrogel was prepared and used to fabricate a tissue scaffold, which can respond to the application of a magnetic field. Briefly, ferrogel was prepared from oxidized hyaluronate, glycol chitosan, adipic acid dihydrazide and superparamagnetic iron oxide nanoparticles via reversible Schiff base formation. This ferrogel, responding to the magnetic field under physiological conditions, showed self-healing behavior and was useful for 3D printing of a dynamic tissue scaffold. Various characteristics of the self-healing ferrogel were investigated. The effect of the magnetic field applied to the scaffold on chondrogenic differentiation of cells was also investigated in vitro. |
