| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.336 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Transplatation of chondrocytes seeded on a marine collagen scaffold into cartilage defects in rabbits |
| 초록 |
The objective of our study was to evaluate reparative tissue formed in chondral defects in an adult rabbit model implanted with cultured autologous articular chondrocytes seed in marine collagen (from sea cucumber) scaffold. Full thickness defects werecreated bilaterally in the weight-bearing surface of the medial femorak condyle of both femora of New Zealand male rabbits. The scaffolds were than repaired using both chondrocytes seeded in the biomaterial and biomaterial alone. Controls were similarly treated but received either no treatment or implants of the delivery substance. Histologic samples from in and around the defect sites were examined 1 and 5weeks after surgery. Statistically significant differences in the quality of the regenerated tissue were found between the grafts carried out with biomaterial carrying chondrocyte cells compared to the biomaterial alone or controls. This study demonstrates the efficacy of this marine collagen (from sea cucumber) scaffold for autologous chondrocytes transplantation. |
| 저자 |
정성인, 이영우, 이상봉, 조성관, 정무상, 이영무
|
| 소속 |
한양대 |
| 키워드 |
Marine collagen; Chondrocytes; Tissue engineering
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| E-Mail |
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