| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Substrate-tethered cellular lipid bilayers for the development of a versatile cell culture platform |
| 초록 |
Tethering lipid bilayers derived from cell membranes on a substrate is a currently emerging strategy in biomedical systems due to their versatility. In the first study, we fabricated a tethered lipid bilayer (tLB) system on titanium using membrane extracted from endothelial cells. Synthesized selenium catalyst was embedded within the tethered endothelial cell membrane to achieve a continuous NO releasing system. Catalytic tLB promoted endothelial cell attachment and inhibited smooth muscle cell growth, which can be applied for cardiovascular devices. In the second study, we fabricated a culture system for stem cells on the tLB derived from pre-differentiated cells, which can facilitate the stem cell differentiation without induction using growth factors. Taken together, our tLB systems pave the way for the diverse cell culture platform for biomedical applications. |
| 저자 |
이주로, Mahmoud A. Elnaggar, 정윤기
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| 소속 |
한국과학기술(연) |
| 키워드 |
Tetherd lipid bilayer; cell culture; cell membrane
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| E-Mail |
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