| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Multi-layered Nanofibrous Scaffold by Spontaneous One-step Electrospinning for Biomedical Applications |
| 초록 |
In the field of tissue engineering, electrospun scaffolds are generally used for mimicking natural ECM structures. Conventional electrospinning method fabricates the two-dimensional sheet-like scaffolds and this structure has several limitations including limited cellular infiltrations. Here, the novel technique was established to fabricate three-dimensional and multi-layered structures that can be used to mimic the patterns of natural ECM structures. Simple process which is mixing any salts in polymer solution before the electrospinning process can induce the self-assembled multi-layered structures. This advanced technique demonstrated probable as an efficient drug delivery system with rapid drug absorption rate and sustained release on the target site by using adeno-associated viral vector. In addition, physical guidance of multi-layered structures can create the layered cellular distribution in vivo. This platform technology covers variety applications of tissue engineering. |
| 저자 |
진규형1, 신미경2, 김승현1, 이해신2, 장재형1
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| 소속 |
1연세대, 2한국과학기술원 |
| 키워드 |
Adeno-associated virus; Tissue engineering; Three-dimensioanl; Self-assembed multi-layerd
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| E-Mail |
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