| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Self-assembled PEGylated albumin nanoparticles for chemo-drug delivery and imaging |
| 초록 |
We used Paclitaxel(PTX) for representative chemo-drug. PTX needs to be dissolved in an oil/detergent-based solvent due to its poor solubility in an aqueous medium. However, the formulation often causes undesirable complications including hypersensitivity reactions and limited tumor distribution, resulting in a lower dose-dependent antitumor effect. Herein, we introduce a facile and oil free method to prepare albumin-based PTX nanoparticles for efficient systemic cancer therapy using a conjugate of human serum albumin (HSA) and poly(ethylene glycol) (PEG). PTX were efficiently incorporated in the self-assembled HSA-PEG nanoparticles (HSA-PEG/PTX) using a simple film casting and re-hydration procedure without additional processes such as application of high pressure/shear or chemical crosslinking. The spherical HSA-PEG nanoparticle mediates efficient cellular delivery, leading to high cytotoxicity in various breast cancer cells. |
| 저자 |
김동민, 정지훈, 이정은, 임수연, 김이슬, 김다훤, 정재백, 조희주
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| 소속 |
성균관대 |
| 키워드 |
Drug dissolution; oil-free formulation; human serum albumin; self-assembled nanoparticle; systemic cancer therapy
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| E-Mail |
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