| 초록 |
Three-dimensional (3D) bioprinting technique has attracted much attention to construct functional tissues and organs. Hydrogels have been widely used as bioink due to their structural similarity to the natural extracellular matrix. Herein, dual cross-linkable hydrogel systems were designed and used as bioink for extrusion-based 3D printing. Hyaluronate was partially oxidized to react with glycol chitosan to form self-healing hydrogels in the presence of adipic acid dihydrazide (chemical cross-linking). Hyaluronate-alginate hybrid polymer was also synthesized and added to physically cross-link the self-healing gels in the presence of calcium ions after the printing process. Various characteristics of dual cross-linked self-healing gels, including viscoelastic properties, stability, chondrogenic differentiation were investigated in vitro. |
