| 초록 |
The tertiary structure of coacervate (growth factor/heparin/polycation) has several significant advantages: high encapsulation efficiency, simple fabrication process in aqueous condition, easy usage during medical operations, protection of cargo growth factors in in vivo physiological condition, and sustained release of incorporated growth factors. Therefore, a successful delivery of therapeutic growth factors facilitates tissue regeneration, especially bone and skin tissues. For bone tissue engineering application, coacervate complex containing BMP-2 and PDGF were coated onto a nanofibrous poly-L-lactic acid scaffold, and inserted in the skull defect of rats to investigate guided bone regeneration. For skin tissue regeneration, especially scar reduction, a sequential delivery of TGFbeta3 and VEGF using coacervates could be a therapeutic approach to reduce the deposition of excess collagen and subsequent scar formation, that are usually resulted from incision and subsequent sutures. |
