| 학회 | 한국공업화학회 |
| 학술대회 | 2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 | 17권 2호 |
| 발표분야 | 포스터-정밀화학 |
| 제목 | Synthesis of 3-amino-1-quinoxalin-2 (1H)-one library: A preliminary solution-phase test |
| 초록 | Our research program has focused on the application of polymer-bound α-diazo-β-ketoesters as key building blocks for the diversity-oriented synthesis of a series of a nitrogen-containing heterocyclic compound libraries, including oxazoles, indoles, imidazolones, pyrazines and pyrazines, etc. In continuation of this work, we are developing the solution and solid-phase synthesis of 3-amino-1-quinoxalin-2(1H)-one library by using ethyl 2-chloro-2-oxoacetate as a key building block. Quinoxaline derivatives exhibit a wide range of biological functions including various antibiotics such as Echinomycin, Levomycin and Actinoleutin that are known to inhibit growth of gram positive bacteria and are active against various transplantable tumours. |
| 저자 | Shanmugavel Ramachandran, 이상협 |
| 소속 | 대구가톨릭대 |
| 키워드 | quinoxaline; Combinatorial solid-phase organic synthesis |
