| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Stabilization of gold nanoparticles by hydrophobically modified Polycations |
| 초록 | Surface modified or polymer stabilized gold nanoparticles have pronounced benefits in biomedical field due to their appreciable interaction with the delivery materials. In our research we have used the hydrophobically modified polycations (i.e. N-acylated chitosan) to stabilize the gold nanoparticles. Aliphatic hydrophobic chain was first grafted on the backbone of chitosan, by N-acylation with fatty acid chlorides having different carbon chain lengths to increase its hydrophobicity1. Chemical modification was studied by fourier transform infrared (FT-IR) spectroscopic analysis. N-acylated chitosan stabilized gold nanoparticles were prepared by graft-onto approach2. Grafting of modified chitosan chains on gold surface was done during the reduction of gold tetrachloroaurate salt with sodium borohydride in presence of aqueous chitosan solution. Polycations stabilized gold nanoparticles were confirmed by the UV-vis spectroscopic analysis. FT-IR spectroscopic analysis confirmed that the backbone of chitosan was not cleaved during the conjugation process and the side chain functional groups remain intact. Transmission electron microscopy (TEM) revealed that the gold nanoparticles were spherical with uniform size of 10~13 nm and well dispersed in physiological pH. Size of the particles was found to be control with the hydrophobic chain length and the distribution of the particles was mono-disperse type as studied by dynamic light scattering (DLS). Amount of polymer on the nanoparticles surface was also controlled with the hydrophobic chain length as revealed by thermo gravimetric analysis (TGA). It is an easy and convenient way for the preparation of well dispersed polycation stabilized gold nanoparticles that can be used as an excellent biomaterial for the immobilization of DNA like polyanions, proteins and drugs. Acknowledgement This work was supported by the Regional Research Centers Program of the Korean Ministry of Educational and Human Resources Development through the Center for Healthcare Technology Development. Reference 1. L.T. Canh, L. Monique, I.S. Pompilia, M.A. Mateescu. J. Control.Release 2003, 93, 1- 13. 2. H. Haizhen, Y. Qiang, Y. Xiurong. J.Colloid and Interface Science 2005, 282, 26-31. |
| 저자 | 레만트바하듀, Santosh Aryal, Shanta Raj Bhattarai, 김치헌, 김성주, 김학용 |
| 소속 | 전북대 |
| 키워드 | nanoparticle; biomaterials; polycation |
