| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation and charaterization of electrospun poly(vinyl alchol)/poly(ε-caprolactone) composite scaffolds via electrospinning |
| 초록 | Recently, nonwoven mats fabricated by electrospinning have attracted much attention as scaffolds because of their inter-connected porous structure, high porosity, and high surface area to volume ratio caused by ultra fine fibers 1,2. In this work, we prepared poly(ε-caprolactone) (PCL)/pol(vinyl alcohol) (PVA) composite scaffold using a double spinneret electrospinning for ensuring cell adhesion, proliferation, and penetration. The morphology of PCL/PVA composite scaffold was studied by scanning electron microscopy (SEM). Polymeric composition in the PCL/PVA composite scaffold was determined by the thermo gravimetric analysis (TGA). The change of polymeric composition in the PCL/PVA composite scaffold after washing was also investigated by TGA. Water contact angles were measured to evaluate the hydrophilicity of PCL/PVA composite scaffold. Results showed that the hydrophilicity of composite scaffold has significantly improved, comparing to hydrophilicity of PCL mat. Moreover, its hydrophilicity was maintained by hydrogen bond between PCL fibers and PVA molecules. This phenomenon was identified by using X-ray Photoelectron Spectroscopy (XPS). NIH 3T3 fibroblast attachment and proliferation was significantly improved on the PCL/PVA composite scaffolds as compared with PCL mats. Acknowledgement This work was supported by the Regional Research Centers Program of the Korean Ministry of Educational and Human Resources Development through the Center for Healthcare Technology Development. References 1. M. S. Khil, S. R. Battarai, H. Y. Kim, S. Z. Kim, K. H. Lee, J Biomed Mater Res, 2005, 72B, 117-124. 2. S. R. Bhattarai, N. Bhattarai, H. K. Yi, P. H. Hwang, D. I. Cha, H. Y. Kim, Biomaterials 2004, 25, 2595–602. |
| 저자 | 이병민1, Shanta Raj Bhattarai1, 김관우1, 박수진2, 김학용1 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | electrospinning; PCL; PVA; scaffold; tisue engineering |
