| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
pH Triggered Photothermal Therapy and Fluorescence Nanoplatform Based on Responsive Polymer-Indocyanine Green Integrated Graphene Oxide |
| 초록 |
We report a pH-dependent, NIR-sensitive, reduced graphene oxide (rGO) hybrid nano-composite synthesize via electrostatic interaction with indocyanine green (ICG) which is designed not only to destroy localized cancer cells but also be minimally invasive to surrounding normal cells. From pH 5.0 to 7.4, the near-infrared (NIR) irradiated hybrid nano-composites showed pH dependent photo-thermal heat generation capability, due to the pH response relief and quenching effects of poly(2-dimethyl amino ethyl methacrylate) [poly(PDMAEMA)] with ICG on a single rGO sheets. The in vitro cellular uptake and local NIR irradiated in vivo tumor ablation after 18 days treatment are very promising to fight against cancer. |
| 저자 |
Shazid Md. Sharker1, 김성민2, 이해신1, 박성영2
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| 소속 |
1KAIST, 2한국교통대 |
| 키워드 |
Photothermal therapy; pH dependence; rGO; Indocyanine green.
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| E-Mail |
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