| 학회 | 한국재료학회 |
| 학술대회 | 2018년 가을 (11/07 ~ 11/09, 여수 디오션리조트) |
| 권호 | 24권 2호 |
| 발표분야 | B. 나노화학/바이오 재료 분과 |
| 제목 | 실란커플링제로 표면처리한 실리카를 포함하는 뼈 재생용 세포담체의 제작과 이의 물성 및 골분화 특성평가 Fabrication and characterization of 3D–printed biocomposite scaffolds based on PCL and silanated silica particles for bone tissue regeneration |
| 초록 | Abstract In this study, we aimed to improve both the mechanical properties and cellular activities of poly(ɛ-caprolactone) (PCL) /silica composite scaffolds by silane modification. We fabricated biocomposite scaffolds using a melt-blending process and 3D bioprinting method (Pure PCL, PSv 5 (5 wt% silica with 95 wt% PCL), PSv 10 (10 wt% silica with 90 wt% PCL), and PSv 20 (20 wt% silica with 80 wt% PCL), respectively). To confirm the performance of this composite scaffold for use as a biomedical scaffold, physical and biological properties were evaluated. Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) mappings of the fabricated composite scaffolds revealed that the silica particles were uniformly embedded in the internal PCL struts. In the mechanical test, by reacting the silica with a silane coupling agent, the composite scaffold showed dramatically improved mechanical properties. Especially, Young’s modulus of the PSv 20 scaffold was 1.4 times higher than that of the pure PCL scaffold. In in vitro tests, the proliferation rate in the PSv 20 was about 1.7 times higher than that of the controlled PCL after 7 days of cell culture. Furthermore, calcium mineralization of osteogenic differentiation for the PSv 20 composite scaffold was observed to be 2.9 times greater than that of the pure PCL scaffold. Based on the results, we suggest that 3D printed silane-modified silica containing PCL scaffolds would be suitable for bone regeneration applications or regeneration therapies. |
| 저자 | 최은정, 박종봉, 윤석환, 김남욱, 김동윤, 서바른, 윤원수, 진송완, 심진형, 전호준 |
| 소속 | 한국산업기술대 |
| 키워드 | Poly(ɛ-caprolactone); Silica; Silane-modification; Composite scaffolds; Guided bone regeneration |
