| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
콜로이드계면화학_포스터 |
| 제목 |
Synthesis of Silicon Nanoparticles for Hyperpolarized 29Si Magnetic Resonance Imaging. |
| 초록 |
Silicon-based nanoparticles have been attracting lots of interest in the field of biomedical applications due to their biocompatibility. Here, we demonstrate two different synthetic approaches in order to yield various nano-sized silicon nanoparticles ranging from 5 nm to 500 nm as hyperpolarized MR contrast agents. i) The particles were synthesized by means of a chemical reduction of micelles. ii) Silica nanoparticles prepared by Stöber method was treated with magnesium at a high temperature so as to produce crystalline Si NPs. The Si NPs show extremely long depolarization times, resulting in high MR image contrast with minimum background signals. In addition, paramagnetic centers on the surface defect sites play a pivotal role in generating MR signal enhancement induced by DNP mechanism, thereby not necessary to add external radical sources. In conclusion, these benefits suggest that the Si NPs can be used as biocompatible and targetable contrast agents. |
| 저자 |
최익장1, 서형림1, 고혜지1, 공경현1, 정기진1, 박희정2, 이영복1
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| 소속 |
1한양대, 2한국기초과학지원(연) |
| 키워드 |
Silicon nanoparticle (Si NPs); Magnetic resonance imaging (MRI); Hyperpolarization.
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| E-Mail |
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