| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
A Release Study Of Double-layer Valsartan and Hydrochlorothiazide Combination Tablets. |
| 초록 |
Valsartan and hydrochlorothiazide combination is used alone or with other medicines to treat high blood pressure. High blood pressure adds to the workload of heart and arteries. This can damage the blood vessels of brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Valsartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that tighten the blood vessels. Hydrochlorothiazide is a thiazide diuretic. It reduces the amount of water in the body by increasing the flow rate of urine. SEM was used to observe the dissolution behavior of valsartan tablet. Crystallinity of valsartan, additives and valsartan tablet was analyzed by using DSC. FT-IR was used to analyze the change of structure between valsartan, additives and valsartan tablet. The in vitro test was carried out to confirm whether valsartan tablet is soluble in intestinal juice. The in vitro test found sustain-release of valsartan tablet. |
| 저자 |
이대훈, 신재훈, 차재근, 전유신, 국연지, 송정은, 강길선
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| 소속 |
전북대 |
| 키워드 |
Valsartan; Hydrochlorothiazide; Spray-dry; Solid Dispersion; combinations
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| E-Mail |
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