| 학회 | 한국화학공학회 |
| 학술대회 | 2017년 봄 (04/26 ~ 04/28, ICC 제주) |
| 권호 | 23권 1호, p.379 |
| 발표분야 | 분리기술 |
| 제목 | Preparation and Pharmaceutical Characterization of Aripiprazole-Orcinol Cocrystal |
| 초록 | Cocrystal formation has been achieved by solution-based or solid–solid reactions. Among them are the evaporation method and grinding method. In this study, the aripiprazole and orcinol were combined to prepare novel co-crystals. Our primary goal was to make co-crystals with increased solubility and dissolution rate. Aripiprazole-orcinol cocrystal powders were prepared by two methods, the evaporation and grinding. Chloroform-ethanol cosolvent was chosen as the optimal solvent in evaporation method. The identification and characterization of cocrystal formation was performed by PXRD and DSC whereas the solubility behavior was analyzed using HPLC Single crystal XRD was also performed to examine the 3D crystallographic structure of cocrystals. It was found that the pharmaceutical properties of aripiprazole-orcinol cocrystals such as the particle size as well as the aqueous solubility were closely associated with the preparation method and process parameters. Experimental procedure and data will be presented in detail in the poster session for scientific discussion. |
| 저자 | 조민용, 최광진 |
| 소속 | 순천향대 |
| 키워드 | 결정화 |
| 원문파일 | 초록 보기 |
