| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
대학원생 구두발표 (발표15분) |
| 제목 |
Microfluidic fabrication of stimuli-responsive drug carriers for controlleddrug release |
| 초록 |
Various stimuli-responsive polymers that respond to internal or external stimuli have emerged as an effective approach for selective drug release at target disease sites. Stimuli-responsive drug carriers (SRDC) in response to tumor-specific pH and reductive conditions can achieve tumor-selective drug release. SRDC that can release drugs by increasing the temperature are efficient for selective accumulation of drugs in the target area. In this study, various SRDC were fabricated via stop-flow lithography (SFL) to achieve controlled drug release. The stimuli-sensitivity and drug release rate of the particles could be fine-tuned by modulating the precursor compositions in the SFL process. In vitro studies demonstrated that encapsulated drugs were efficiently released from the particles under tumor conditions or temperature increase. This result confirmed that SRDC were successfully fabricated by SFL and showed controlled drug release in response to various tumor-related stimuli. |
| 저자 |
최대건1, Hyeon Ung Kim2, Yoon Ho Roh2, 봉기완2, 심민석1
|
| 소속 |
1인천대, 2고려대 |
| 키워드 |
stimuli-responsive polymer; stop-flow lithography; controlled drug release
|
| E-Mail |
|
