| 초록 |
In this study, we developed a non-invasive strip sensor to concurrently diagnose diabetes and dry eye syndrome through tear collection. The strip sensor was composed of a tear collector designed to not cause eye irritation, and the sensor units for multiple disease diagnosis, where we applied the electrochemical means to detect glucose in tear and tear meniscometry to diagnose dry eye syndrome. In vivo experiment was performed on two different rabbit groups, which possessed normal conditions and both hyperglycemia and dry eye syndrome, respectively. Thus, when the strip sensor was contacted with the inferior palpebral conjunctiva of the rabbit eye for 15 seconds, a significant difference was observed in tear glucose level and collected volume of tear fluid between the animal groups (p < 0.0001) without any apparent eye tissue damage. The outputs measured with the sensor herein showed a high correlation to those from the conventional diagnostic methods in clinical use. |
