| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Endothelial ER71/ETV2 activation require for vascular regeneration |
| 초록 |
The ETS factor ETV2 (aka ER71) is essential for the formation of hematopoietic and vascular systems. Despite its indispensable function in vessel development, ETV2 role in adult angiogenesis has not yet been addressed. We have therefore investigated the role of ETV2 in vascular regeneration. While ETV2 expression was not detectable under steady state conditions, its expression was readily observed in endothelial cells following injury. Mice lacking endothelial ETV2 displayed impaired neovascularization. Lentiviral ETV2 expression in ischemic hindlimbs led to improved vessel formation. Our study demonstrates a novel obligatory role for the ER71 in postnatal vascular repair and regeneration. |
| 저자 |
Changwon Park1, Tae-Jin Lee2, Fang Liu3, Suk Ho Bhang2, Kyunghee Choi3
|
| 소속 |
1Emory Univ. School of Medicine, 2Sungkyunkwan Univ., 3Washington Univ. School of Medicine |
| 키워드 |
|
| E-Mail |
|
