| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I(영어발표) |
| 제목 |
Convenient and effective photoinduced grafting of biocompatible polymers on the super-engineering plastics |
| 초록 |
Since poly(ether-ether-ketone) (PEEK) has sufficient mechanical strength and stability, they are applicable as next-generation medical materials in place of metals and ceramics. PEEK generates radicals on the surface by UV irradiation and forms polymer graft layer. 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymer and heparin (Hep) were modified on the surface of PEEK by the surface modification method. On the surface of the PEEK substrate with 2-(methacryloyloxy)ethyl trimethylammonium chloride (TMAEMA)/MPC units (PMT), the amount of immobilized Hep increased with the TMAEMA unit. Adhesion of platelets was suppressed on the surface with the MPC unit ratio until 60/40. As the blood clotting time was 10 min on the surface of TMAEMA/MPC unit ratio as 0/100, the longest clotting time was observed at Hep/PMT-graft-PEEK (60/40) as 40 min. This surface modification technology will apply for development of PEEK-based an artificial valve. This research was supported by AMED, Japan. |
| 저자 |
Kazuhiko Ishihara1, Kyoko Fukazawa1, Satoshi Yanokuchi1, Tetsuji Yamaoka2, Yuuki Inoue1
|
| 소속 |
1The Univ. of Tokyo, 2National Cerebral and Cardiovascular Center |
| 키워드 |
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| E-Mail |
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