| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Preparation of L-PLA Microspheres containg 5-FU using Supercritical Carbon Dioxide. |
| 초록 |
5-fluorouracil (5-FU) is widely used chemotherapeutic agent for the treatment of metastatic breast cancer. To obtain maximal efficacy with minimal systemic side-effects, many studies have been carried out to achieve the sustained release of 5-FU. Thus, a water-soluble anti-cancer drug, 5-FU was encapsulated in microspheres of poly(L-lactide) using supercritical fluid. Micro- or nano-size drug particles were produced using aerosol solvent extraction system (ASES) and determine the physicochemical characteristics of the developed microspheres. The operating conditions were 35°c of temperature, 130 bar of pressure and 5~40% (w/w) of drug/polymer concentrations in solutions. Our results in dicate that ASES process was more efficient than traditional method. |
| 저자 |
정주희1, 정인일2, 이상윤1, 임교빈1, 유종훈1
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| 소속 |
1수원대, 2연세대 |
| 키워드 |
5-FU; L-PLA; Supercitical Fluid
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| E-Mail |
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