| 초록 |
The size, conformation, and surface properties of nanoparticles have been optimized for drug delivery applications. However, when nanoparticles flow through the bloodstream, they interact with various plasma proteins, leading to the formation of the protein layer on top of the particle surface, a process called protein corona. This protein-corona formation influences the conformation and surface properties of nanoparticles, which may increase or reduce the targeting efficiency. To understand this, we performed molecular dynamics simulations of plasma proteins adsorbed onto cationic, anionic, and neutral nanoparticles. The following topics will be presented: (1) the formation of protein corona via the adsorption competition between plasma proteins; (2) the effect of protein corona on diffusivity and hydrodynamics of the nanoparticle; (3) the effect of protein corona on the binding between nanoparticle and cell membrane. This work aids in the rational design of the nanoparticle-protein complex for drug delivery applications. |
