| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 봄 (05/01 ~ 05/03, ICC JEJU) |
| 권호 |
17권 1호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Synthesis of Neuraminidase Inhibitors and Modeling Studies |
| 초록 |
Two sialic acid recognizing proteins, hemagglutinin and sialidase, on the viral surface have been shown to be crucial in invasion and have provided many exciting opportunities for rational structure-based drug discovery of anti-influenza agents. In order to study important recognition features required in the inhibition of sialidase, we synthesized a range of sialyl nucleoside mimetics. D-Fructose was used as a substrate for the efficient preparation of 1,2,3-triazole derivatives using the copper-catalyzed azidealkyne Huisgen cycloaddition. As a preliminary study, a small library of 1,2,3-triazole-linked D-fructose derivatives has been synthesized which will be screened for its influence on influenza neuraminidase inhibitory activity. The computational simulation by molecular docking procedure was conducted for the prediction of interactions between ligand and sialidase binding pocket. |
| 저자 |
김태우1, Tasneem Islam2, 임융호3, 정강연1
|
| 소속 |
1강릉원주대, 2Roosevelt Univ..IL. USA, 3건국대 |
| 키워드 |
Neuraminidase |
| E-Mail |
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