| 초록 |
Paclitaxel is one of the most effective therapeutic agents for cancer therapy. Due to its extremely low aqueous solubility, paclitaxel has been formulated by dissolving in a solution of ethanol mixed cremophor EL (Taxol). However, there are serious side effects resulted from this solvent system. Therefore, many researches have been performed to overcome solvent-related toxicity. In this study, we developed human serum albumin nanocapsules cross-linked by PEG containing paclitaxel with improved water solubility. Methylene chloride containing paclitaxel and 6 arm PEG-succinimidyl succinate was emulsified by sonication in aqueous solution containing HSA. The resultant particles had a size of 200~300 nm and negative surface charge. Hph-1-PTD-conjugated nanocapsule induced a remarkable cancer cell death and an accumulation in tumor, as compared with unmodified one. Our study demonstrated that HSA nanocapsules hold great promise for broad biomedical applications. |
