| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.175 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | In vitro anti-tumoral activity test of Taxol using SMEDDS |
| 초록 | The current clinical formulation of Taxol has a promising clinical activity against a wide variety of tumors. Because of overcome many problem (poorly water solubility and the oral delivery of such drug is associated with implications of low bioavailability), various formulation strategies have been reported including the use of surfactants, mamoparticles, solid dispersions and lipids. We use self-microemulsifying drug delivery system(SMEDDS) containing paclitaxel. SMEDDS are isotropic mixtures of an oil, surfactant, cosurfactant, and drug. They form fine oil-in-water emulsions when introduced into aqueous media under mild agitation. The in vitro anti-tumoral activity of SMEDDS developed in this work was assessed by a human breast cancer cell line MCF7 and compared to the in vitro anti-tumoral activity of the Taxol and Genexol -PM. The results of cytotoxicity, maximum tolerated dose (MTD) and cell viability suggest that SMEDDS may have a great advantage over present-day chemotherapy with Taxol and Genexol -PM. Acknowledgment : This work supported by KMOCIE |
| 저자 | 김선화;신필경;강복기;정상영;조선행;강길선;이해방 |
| 소속 | 전북대 |
| 키워드 | |
