| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Synthesis and physicochemical properties of acetylated glycol chitosan |
| 초록 |
Glycol chitosan (GC) is a water soluble chitosan derivative being proposed as a new material for pharmaceutical and bioengineering applications. With the goal of extending the application of GC for use in drug delivery system, GC was selectively N-acetylated using acetic anhydride in mild conditions. Acetylated glycol chitosan (AC-GC) was verified by both 1H NMR and FT-IR spectroscopy and their physicochemical properties were characterized in terms of solubility, biodegradability, self-assembling and sol-gel transition properties. The degree of N-acetylation (DA) was modulated approximately from 10% to 88% by varying the feed molar ratio of acetic anhydride to GC. Biodegradability of GC was further improved by the N-acetylation, AC-GC with higher DA leading to faster biodegradation. These biocompatible and degradable AC-GCs could be a new promising material for drug delivery system and biomedical applications. |
| 저자 |
이정정, Thanh Huyen Tran, 허강무
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| 소속 |
충남대 |
| 키워드 |
glycol chitosan; acetylation; physicochemical property
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| E-Mail |
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