| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Tunable Engineering of Heparinized Injectable Hydrogels for Affinity-Based Sustained Delivery of Bioactive Factors |
| 초록 |
In situ-forming injectable hydrogel is reported based on pH- and temperature-responsive copolymers engineered with heparin for sustained delivery of bioactive factors. In order to develop such hydrogels, pH- and temperature-responsive copolymers based on poly(ethylene glycol) and poly(urethane sulfamethazine) (PEG-PUSSM) are synthesized and acrylated, and coupled with thiolated heparin through Michael-addition reaction. The heparin in the bioconjugates (Hep-PUSSM) is tuned to control the release of heparin-binding bioactive factors. The bioconjugate sols at room temperature transform to viscoelastic gel in physiological conditions, indicating that heparin modification doesn’t affect sol–gel transition. The bioconjugates effectively bind with bioactive factors (VEGF) through simple mixing, and the release is controlled over a period of 4 weeks without an initial burst. As a result, the implantation of VEGF-loaded bioconjugate gel induces angiogenesis throughout the hydrogel network. |
| 저자 |
김성한1, Thavasyappan Thambi1, Jae Seung Lym1, V. H. Giang Phan2, 이두성1
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| 소속 |
1Sungkyunkwan Univ., 2Ton Duc Thang Univ. |
| 키워드 |
injectable hydrogels; heparinization; VEGF; biodegradation; sustained release
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| E-Mail |
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