| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Novel antibiotic delivery using graphene oxide immobilized surfaces |
| 초록 |
Implant-related infection is a noteworthy issue because of their negative effect to the success of implantation, and the cost of treatment. To solve this problem, the development of antimicrobial surface has been considered as an urgent mission. Herein, we demonstrated that graphene oxide (GO)-immobilized TiO2 surface is an efficient carrier for the local delivery of antibiotic. The phenol-functionalized GO derivative was synthesized and immobilized on TiO2 under the catalysis of tyrosinase, following by the loading of doxycycline hyclate (Dox). The modified surface was able to carry 36 µg of Dox and ensured the release for a month. These surfaces also showed good antibacterial activity against both E. coli and S. aureus, without the cytotoxic effect on hDFBs. It is expected that the release of Dox from GO-immobilized surfaces can solve the pressing need for enhanced infection control |
| 저자 |
TRAN DIEU LINH, Thai Thanh Hoang Thi, Phuong Le Thi, 박기동
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| 소속 |
아주대 |
| 키워드 |
Antibacterial surface; tyrosinase; graphene oxide; doxycycline
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| E-Mail |
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