| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
약물 및 유전자 전달용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Redox-sensitive and stabilized heparin-Pluronic nanogels for efficient intracellular drug delivery |
| 초록 |
Polymeric nanocarriers for intracellular delivery have many limitations, such as short half-life, non-specific drug release, although it has been continuously potentiated. Our group also has developed a potential nanocarrier, nano-sized heparin-based hydrogels, suffering from low stability and non-specific release of drugs. Herein, thus a heparin-Pluronic (HP) nanogel was strengthened by crosslinking with disulfide bond. The disulfide crosslink in HP nanogel may enable glutathione-sensitive release of a drug in the intracellular region and long-lasting circulation without dissociation. In vitro release study showed that the drug release time extended about 3 folds comparing to unmodified heparin-Pluronic nanogels. Besides, the release time increased 2.5 folds in presence of 5.0 mM glutathione than the absence of glutathione. These results suggest that disulfide-crosslinking may facilitate the improved stability and release profile of HP nanogels for efficient intracellular delivery. |
| 저자 |
Dai Hai Nguyen, 최종훈, 정윤기, 박기동
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| 소속 |
아주대 |
| 키워드 |
Redox sensitive; Disulfide cross-linked; Nanogel; Thiolated heparin-Pluronic; Drug delivery system (DDS)
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| E-Mail |
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