| 초록 |
Skin tissue is regenerated by the combinational function of skin cells, extracellular matrix (ECM), and bioactive molecules. Here, we developed self-assembling supramolecular drug delivery hydrogels to mimic skin tissue regeneration process (Figure 1). The supramolecular hydrogels were prepared by the host-guest interaction of cyclodextrin modified gelatin (GE-CD) and adamantane modified hyaluronate (Ad-HA) with human growth hormone (hGH) conjugation for accelerated skin tissue regeneration. In vitro, GE-CD/Ad-HA-hGH hydrogels showed highly facilitated cell growth by RGD peptide of GE and the controlled hGH delivery. We could also observe the improved skin tissue regeneration by the facilitated fibroblast proliferation with angiogenesis in vivo. Taken together, we could confirm the feasibility of biomimetic supramolecular drug delivery GE-CD/Ad-HA-hGH hydrogels for various tissue engineering applications. |
