| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Co-delivery of antigen and immune response modulator using nano micelle-generating dissolving microneedles for enhanced cancer vaccination |
| 초록 |
Efficient delivery of tumor antigens and immunostimulatory adjuvants into lymph nodes is crucial for the maturation and activation of antigen-presenting cells (APCs), which subsequently induce adaptive antitumor immunity. Dissolving microneedle (DMN) has been considered as an promising device for transcutaneous immunization due to its superior ability to deliver vaccines through the skin layer. Here, we develop pluronic-based dissolving MNs in situ that generate nanomicelles (NMCs) upon their dissolution after cutaneous application, which facilitate the efficient encapsulation of poorly water-soluble toll-like receptor 7/8 agonist (R848) and the delivery of hydrophilic antigens. Application of MNs containing tumor model antigen (OVA) and R848 to the skin of EG7-OVA tumor-bearing mice induced a significant level of antigen-specific humoral and cellular immunity, resulting in remarkable anti-tumor activity. |
| 저자 |
임수연, 김이슬, 김다훤, 조희주, 김동민, 정지훈
|
| 소속 |
성균관대 |
| 키워드 |
microneedle; immunotherapy
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| E-Mail |
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