| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_정밀화학 |
| 제목 |
Total synthesis of isoimerubrine and its analogs |
| 초록 |
Isoimerubrine is an attractive synthetic target because of its fascinating fused structure of the seven-membered tropone ring and isoquinoline moiety as well as its interesting biological activities. Based on our previous total synthesis of pareitropone, the key synthetic step for isoimerubrine is the radical anionic coupling of phenolic nitronate for the construction of the annulated tropone ring. We have synthesized the trimethoxy-substituted tropoloisoquinoline rings of isoimerubrine containing the chlorine functional group. They could be useful for the preparation of various analogs of isoimerubrine because the chlorine group could be readily converted into other functional groups. Using this strategy, we have successfully synthesized isoimerubrine and its regioisomer by simple methoxylation. |
| 저자 |
장세욱, 박권주, 이홍원, 이병일, 김영규
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| 소속 |
서울대 |
| 키워드 |
Total synthesis; Biological effect; Natural product; Radical anionic coupling; Regioisomer; Isoimerubrine
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| E-Mail |
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