| 학회 |
한국고분자학회 |
| 학술대회 |
2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 |
30권 2호 |
| 발표분야 |
탄소나노튜브 및 고분자 복합재료 |
| 제목 |
The Polymerization of Fibrinogen Coupled with MWNTs using plasma transglutaminase (Factor XIII) |
| 초록 |
Carbon nanotubes (CNTs) have many interesting and unique properties to be used in a variety of biological and biomedical systems. For the development of its potential applications, various methods of functionalization of CNTs have being developed to interface CNTs with organic and inorganic materials, as well as biological macromolecules. The latter is gaining popularity because of potential applications in biosensor development, bioelectrochemistry, biomedical devices, and cellular delivery of peptides and proteins. In this study, we conducted the amide coupling between MWNT-COOH and fibrinogen (FBG). FBG is an acute phase defensive protein that participates as a core protein in the final phase of blood coagulation. The main function of FBG is to promote the formation of three-dimensional network of fibrin fibers that forms blood clots. After coupling of FBG with MWNT-COOH, the polymerization of MWNT-FBG to MWNT-Fibrin was conducted successfully adding activated plasma transglutaminase (Factor XIII). MWNT-FBG and MWNT-Fibrin were characterized by using FT-IR spectroscopy, transmission electron microscope (TEM), and energy dispersion of X-ray spectroscopy (EDX) coupled with transmission electron microscope(TEM). In conclusion, the MWNT-FBG still maintained the fibrinogen property, where Factor XIII were able to polymerized the MWNT-FBG to MWNT-Fibrin. |
| 저자 |
김미진1, 장준호1, 한정훈1, 최인성2, 안성수3, 백현종1
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| 소속 |
1부산대, 2한국과학기술원, 3(주)피플바이오 |
| 키워드 |
Carborn nanotubes; Firinogen; Plasma transglutaminase (Factor XIII)
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| E-Mail |
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