| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Formulations Based on Hyaluronic Acid and TNF-Related Apoptosis-Inducing Ligand as the Injectable Protein Delivery System |
| 초록 |
Although Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) is considered as the potent therapeutics for tumors, its instability and rapid aggregation in biological fluids remains problematic. In this study, an injectable hyaluronic acid (HA)-based TRAIL formulation was developed for controlled release of TRAIL while maintaining its stability in vivo. The HA/TRAIL formulations were prepared by simple ionic complexation, and their physicochemical properties were investigated. To confirm formation of TRAIL/HA complex, complex sizes and zeta potential were measured using dynamic laser scattering and the zetasizer. Release tests of TRAIL from HA complex were carried out in vitro using the membrane dialysis method. Bioactivity of the TRAIL/HA complex was evaluated using a HeLa cell line. According to the result, the TRAIL/HA complex formation might be useful as the injectable delivery system of TRAIL for treating tumors. |
| 저자 |
나성주1, 이슬기2, 채수영3, 김광명2, 박재형1, 권익찬2, 정서영1, 이강춘3
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| 소속 |
1경희대, 2한국과학기술(연), 3성균관대 |
| 키워드 |
Hyaluronic acid(HA); Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand(TRAIL); fomulation; protein delivery; stability
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| E-Mail |
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