| 초록 |
As neural engineering is becoming more complex, the importance of polymeric biomaterials is getting more important. Moreover, the emerging of Optogenetics requires transparency for those biomaterials. Therefore, biomaterials for modern, complex neural engineering need to satisfy four requirements; high transparency, biocompatibility, easy processibility, proper mechanical property. However, most polymeric materials do not fulfill them. Here, we suggest a uv curable polysiloxan acrylate which satisfy them. Firstly, we demonstrated a hierarchical structure with simple process achieved by combining conventional, and unconventional lithography. Secondly, It shows excellent biocompatibility based on immunohistochemistry and cell viability test. it shows extremely high transparency at visible-NIR range. Finally, It has high flexibility but enough strength for brain implantation, which means only minimal tissue damage is occurs. The neural probe was implanted to a living mouse brain with minimal tissue damage, and local field potential was recorded. Taken together these results suggest that the material might have excellent potential for being used for advanced neural engineering. |
