| 초록 |
In photomedicine, visible light is used for various applications as is well known. When visible light is irradiated on the skin, the shorter the wavelength of light, the less penetrating. Thus, blue light with the shortest wavelength has limitations in its medical application despite having high energy. In this work, we prepared hyaluronic acid (HA) based nanocarriers for transdermal delivery of up-conversion (UC) dye as light source, which can convert the irradiated light into a shorter wavelength light, and confirmed a blue light emission in the skin. By UC analysis, UC dye loaded NPs emitted stably blue light, and further analysis in porcine skin tissue dispersant showed the applicability of our NPs in skin tissue. In addition, the skin permeation test showed the permeability of the NPs through the variation of blue light intensity in skin cross-section. With these results, our HA-based NPs are suitable for transdermal delivery of UC dye and can be effective phototherapy platform. |
