| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
NIR dye loaded micelles for CD-44 based targeted photo-thermal therapy. |
| 초록 |
Photo-thermal therapy (PTT) is a light based molecular targeted cancer therapy, which uses electromagnetic radiations most often in infrared wavelength for the treatment of cancer. In this study, we are proposing NIR dye loaded CD 44 targeted micelles of 280 nm size. Upon injection into the body, NIR dye loaded CD 44 targeted micelles will be distributed throughout the body and selective accumulate in tumor by 24 hrs. Upon irradiation of the tumor site by 808nm laser (2W/cm2) for 5min, tumor cells in the area of illumination would be killed by the heat produced by the NIR dye loaded CD 44 targeted micelles and subsequently reduced the tumor burden. The results of tumor reduction study demonstrated significant tumor reduction by CD 44 targeted micelles upon laser irradiation, however CD 44 targeted micelles without laser irradiation don’t elicit any tumor reduction. |
| 저자 |
UTHAMAN SAJI1, 박인규2, Rajendrakumar Santhosh Kalash2, Cherukula Kondareddy3, 허강무1
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| 소속 |
1Chungnam National Univ., 2Chonnam National Univ., 3chonnam national Univ. |
| 키워드 |
photo-thermal therapy; laser; tumor; micelles.
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| E-Mail |
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