| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Effect of Preparation Methods on Release Behavior of Valsartan-loaded Polyoxalate Microspheres |
| 초록 |
The purpose of this study was to prepare and evaluate valsartan-loaded microspheres from various preparation methods of O1/O2/W and O1/O2/O3. Also, this study was to prepare from kind of solvent. Valsartan-loaded POX microspheres were characterized for the drug load, out/inner surface morphology and in vitro drug release. Physicochemical characters and morphology of prepared microspheres were evaluated by X-ray diffraction (XRD), differential scanning calorimeter (DSC), Fourier transform infrared (FT-IR) and scanning electron microscopy (SEM). Through the study results, it shows that the skin layer of the prepared microspheres is comprised of POX and valsartan was encapsulated within the microspheres. Also, the degradation of microspheres and the drug release were obtained from each SEM and in vitro test for 15 days. This research was supported by NRF-2012M3A9C6050204, Bio-industry Technology Development Program (KMFAFF, 112007-05-2-SB010) and the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
이천중, 김수영, 차세롬, 김은영, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Valsartan; In vitro; Sustained release; POX; O1/O2/W; O1/O2/O3.
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| E-Mail |
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