| 초록 |
Cell therapy has been suggested as a treatment modality for ischemic diseases, but the poor survival and engraftment of implanted cells limit its therapeutic efficacy. To overcome the efficacy of cell therapy, we used electrical stimulation (ES) derived from a wearable solar cell to induce angiogenesis in ischemic tissue. Angiogenesis in a mouse ischemic hindlimb model was enhanced by solar-cell-generated ES applied to the ischemic region, which promoted migration of MSCs toward the ischemic site and upregulated expression of angiogenic paracrine. Importantly, solar-cell-generated ES promoted the formation of capillaries and arterioles at the ischemic region, attenuated muscle necrosis and fibrosis, and eventually prevented loss of the ischemic limb. This study shows the feasibility of using solar-cell ES as a novel treatment for therapeutic angiogenesis. |
