| 초록 |
Vitamin C, also known as L-Ascorbic acid(AA) is one of the interesting and well-known acids in nature which has bioactivity and anti-oxidation property. Also, vitamin E is a group of eight compounds that includes four tocopherols and four tocotrienols. Among all tocopherol isoform, α–tocopherol(α-TO) has the highest antioxidant and biological activity and can be used in cosmetic, pharmaceutical, and food industry. However AA and α-TO are readily oxidized by light, air, oxidizing agents or heat, resulting in the reduction of their antioxidant value. Cyclodextrin(CD) can enhance the solubility and chemical stability of compounds in aqueous solution and finally increase the bioavailability. The oxidized β-CD, carboxylic-β-CD was synthesized from TEMPO, NaBr, NaClO4. C-β-CD-AA and its conjugation with vitamins were synthesized from C-β-CD with ascorbic acid or α–tocopherol by using DCC and DMAP in DMSO and characterized by FT-IR, 1H-NMR, 13C-NMR spectroscopies. |
