| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
24 h Extended Release of Nifedipine-Solid Dispersion Using Multi-layer Tablet. |
| 초록 |
Nifedipine(ND) is mainly used for treatment of antianginal and antihypertensive. It is small water-soluble drug. So we prepared solid dispersion for improvement of dissolution rate. However, it has the limitation of maximum dose about 30 mg/day. Also, It has half-life of 1.5 to 2 h. It is essential to extend the release of ND. Therefore, the aim of this study is to control the release of ND through the multi-layer formulation for 24 h. The out layer of tablet used gel-forming polymers as release controlling agent. The prepared solid dispersion is analyzed by SEM, FT-IR, XRD and DSC. The prepared multi-layer tablet is characterized by swelling and water uptake & matrix erosion assays. The release behavior of ND from the prepared multi-layer tablet is confirmed through in vitro assay. This study is suggested that the multi-layer formulation has an impact potential in oral pharmaceutical industry. This research was supported by MIFAFF (112007-05-1-SB010) and MEST (2012M3A9C6050204). |
| 저자 |
박상미, 김영래, 이정환, 김혜윤, 이소진, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Nifedipine; 24 h extended release; Multi-layer formulation; Wet granulation; Zero-order release.
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| E-Mail |
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