| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
International Symposium on Advanced Biopolymers (의료용 고분자 부문위원회, 영어발표) |
| 제목 |
Polymeric nanoparticle for gene and drug delivery |
| 초록 |
In this research, siRNAs were utilized for two functions: therapeutic agent and cross-linking building block for nanoconstruct. We developed a novel nanoconstruct (NC) which was composed of siRNA-conjugated natural polymers through spontaneous hybridization of sense- and antisense strand siRNAs conjugated to dextran polymer. This NC is a condensed nano-sized particle through gathering each polymer chains by siRNA double helix formation. Increasing the concentration of NC inhibited gene expression up to about 40 %. Herein, we also designed self-assembled nanoparticles for Paclitaxel (PTX) delivery toward tumor cell. Self-assembled nanoparticles were constructed through host-guest chemistry between PTX and β-cyclodextrin (β-CD). CD and PTX are covalently conjugated with poly maleic anhydrides via ester linkage that provide higher solubility of nanoparticles. It was revealed that this nanoparticle effectively inhibited the tumor growth in vivo by delivering PTX into tumor site. |
| 저자 |
Won Jong Kim |
| 소속 |
Center for Self-assembly and Complexicity |
| 키워드 |
siRNA; nanoconstruct; drug delivery
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| E-Mail |
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