| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 | 20권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Preparation of Chitosan-EGF Conjugates (CEC) and Its Biocompatibility |
| 초록 | Epidermal Growth Factor (EGF) has been reported that EGF accelerates self-renewal capacity in epidermal cell. The use of EGF can lead to great effect in wound repair and anti-wrinkle effect. But in the body, the half-life of EGF is too short to influence the biological activity when utilized in free form. Growth Factors can be stabilized by photo-immobilization. Chitosan derivative was prepared by akalization, tosylation, azidation, and reduction of chitosan. The structure of chitosan derivative was confirmed by FT-IR, 1H NMR and elementary analysis. EGF was immobilized with chitosan derivative by using carbodiimide. In conclusion, CEC didn’t show any cytotoxicity. So chitosan derivative is suitable to immobilize of growth factor. Acknowledgements This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT and future Planning (No. NRF-2014R1A2A1A11052623) |
| 저자 | 김재원, 김은혜, 정진홍, 한가득, 노승현, 손태일 |
| 소속 | 중앙대 |
| 키워드 | epidermal growth factor (EGF); chitosan; photo-immobilization; biocompatibility |
