| 학회 |
한국공업화학회 |
| 학술대회 |
2009년 봄 (04/15 ~ 04/17, 호텔인터불고(대구)) |
| 권호 |
13권 1호 |
| 발표분야 |
콜로이드계면화학 |
| 제목 |
pH-dependent release from monoolein cubic phase containing acidic polypeptides |
| 초록 |
Monoolein (MO) in water forms a lamellar structure, an inverted hexagonal phase, or a bicontinuous inverted cubic phase. Since the cubic phases are biocompatible and biodegradable, they could be used as drug delivery vehicles. In this study, cubic phases containing acidic polypeptide were prepared by hydrating MO using the polymer solution. The cubic phase was pH-sensitive in terms of release. The polypeptide in the water channels of cubic phases will take a contracted form or an extended from, depending the pH of medium. As a result, diffusion through the water channels would be varied in a pH-dependent manner. This may account for the pH-dependent release. |
| 저자 |
권택관, 강미경, YANG XIA, 홍연지, 김진철
|
| 소속 |
강원대 |
| 키워드 |
cubic phase; acidic polypeptides; monoolein
|
| E-Mail |
|
