| 학회 |
한국재료학회 |
| 학술대회 |
2009년 가을 (11/05 ~ 11/06, 포항공과대학교) |
| 권호 |
15권 2호 |
| 발표분야 |
D. Health and Biological Materials(생체 및 의용재료) |
| 제목 |
Simvastatin loaded porous poly(lactide-co-glycolide) (PLGA) microspheres as delivery systems strategies for injuring tissue and in vitro study |
| 초록 |
Regeration of natural tissues or to create biological substitutes for defective or lost tissues and organs through the use of cells. In addition to cells and their porous, drugs are required to promote tissue regeneration. Therefore, the present studies were prepared using simvastatim loaded porous poly(lactide-co-glycolide) (PLGA ) by double emulsion solvent evaporation water-in-oil-in-water technique (W/O/W) as drug delivery system strategies for injuring tissue. The resulting microspheres were evaluated for morphology, particle size, encapsulation efficiency, degradation of PLGA microspheres in vitro drug release and in vitro cell viability. Scanning electronic microscopic (SEM) showed that the porosities of the particles was changed by experimental conditions and cultured cells were attached well on porous microspheres surface. The X-ray diffraction (XRD) and differential scanning calometry (DSC) analysis indicate that simvastatim was highly dipersed in the microsphere at amorphous state. |
| 저자 |
Trinh-Quang Bao1, Yang-Hee Kim2, Byong-Taek Lee3
|
| 소속 |
1Department of Biomedical Engineering and Materials, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
delivery systems; In vitro study; Porous PLGA microspheres; Simvastatim
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| E-Mail |
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